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Br J Dermatol. 2008 Jul;159(1):132-6. doi: 10.1111/j.1365-2133.2008.08614.x. Epub 2008 Jul 1.

Latex allergy: new insights to explain different sensitization profiles in different risk groups.

Author information

1
CICS - Centro de Investigação em Ciências da Saúde, University of Beira Interior, 6201-001 Covilhã, Portugal.

Abstract

BACKGROUND:

Differences in latex allergen sensitization profiles have been described between children subjected to repetitive surgical interventions and health care workers (HCW). 'Major' allergens for patients with spina bifida are Hev b 1, 3 and 7, while for HCW, 'major' allergens are Hev b 2, 5, 6.01 and 13. The reason for these differential sensitization profiles is currently unknown.

OBJECTIVES:

To investigate latex allergen profiles on internal and external surfaces of natural rubber latex gloves.

METHODS:

Eighty-two samples of commonly used surgical gloves (41 glove brands) were used for analysis. Specific allergen levels of Hev b 1, 3, 5 and 6.02 on both surfaces of the gloves were quantified using an enzyme immunometric assay, a FITkit (FIT Biotech, Tampere, Finland).

RESULTS:

Differences in allergen levels were observed between internal and external surfaces of all glove types. Concentrations of Hev b 1 and Hev b 3 were significantly higher on external surfaces, while internal surfaces had higher allergen levels of Hev b 5 and Hev b 6.02. Analysis of surgical and examination gloves, powdered and nonpowdered gloves also showed that the content of Hev b 5 and Hev b 6.02 was significantly higher on internal surfaces while that of Hev b 1 and Hev b 3 was higher on external surfaces.

CONCLUSIONS:

Our study showed different allergen profiles on internal and external surfaces of natural rubber latex gloves. These results may suggest a relationship between latex allergen localization and sensitization routes in different risk groups.

[Indexed for MEDLINE]

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