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Intrauterine infection with coxsackievirus: is it a cause of congenital cardiac malformations?

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1
Department of Perinatal Medicine Sioux Valley Hospital University of South Dakota School of Medicine 1201 S. Euclid Avenue, Ste. 204 Sioux, Falls, SD 57105, USA.

Abstract

BACKGROUND:

Although maternal infections with coxsackievirus during pregnancy are relatively common, fetal infections are quite rare. Coxsackievirus infection in utero has been associated with myocarditis, but has not been proven a teratogen.

CASE:

A patient whose fetus had structural cardiac anomalies and hydrops was found to have an intrauterine infection with Coxsackie B-1 virus, proven by virus isolation from the amniotic fluid. This infection led to increasing intrauterine hydrops and subsequent neonatal death.

CONCLUSION:

This interesting association of intrauterine infection with Coxsackie B virus and structural cardiac anomalies in the fetus warrants further investigation.

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