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Br J Cancer. 2008 May 20;98(10):1641-5. doi: 10.1038/sj.bjc.6604365. Epub 2008 May 13.

SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue.

Author information

1
St Vincent's University Hospital, Dublin 4, Ireland.

Abstract

The prevalence and clinical relevance of SNIP/p140Cap has not been extensively investigated. Here SNIP/p140Cap mRNA expression was studied in 103 breast tumour biopsies, where it was detected in approximately 37% of tumour specimens, but not in any normal breast specimens. Expression correlated significantly with unfavourable overall survival. This suggests that SNIP/p140Cap may be a useful diagnostic and prognostic marker for breast cancer and its expression in breast cancer, but not in normal breast tissue, suggests that it may have potential as a therapeutic target.

PMID:
18475297
PMCID:
PMC2391132
DOI:
10.1038/sj.bjc.6604365
[Indexed for MEDLINE]
Free PMC Article

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