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Nat Rev Genet. 2008 Jul;9(7):509-15. doi: 10.1038/nrg2363. Epub 2008 May 13.

Use and misuse of the gene ontology annotations.

Author information

1
Carnegie Institution for Science, Department of Plant Biology, 260 Panama Street, Stanford, California 94305, USA. rhee@acoma.stanford.edu

Abstract

The Gene Ontology (GO) project is a collaboration among model organism databases to describe gene products from all organisms using a consistent and computable language. GO produces sets of explicitly defined, structured vocabularies that describe biological processes, molecular functions and cellular components of gene products in both a computer- and human-readable manner. Here we describe key aspects of GO, which, when overlooked, can cause erroneous results, and address how these pitfalls can be avoided.

PMID:
18475267
DOI:
10.1038/nrg2363
[Indexed for MEDLINE]

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