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Nature. 1991 Feb 21;349(6311):669-76.

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments.

Author information

1
Laboratory of Cell Biology, Medical School, University of Utrecht, The Netherlands.

Abstract

Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.

PMID:
1847504
DOI:
10.1038/349669a0
[Indexed for MEDLINE]

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