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Cell Host Microbe. 2008 May 15;3(5):275-7. doi: 10.1016/j.chom.2008.04.007.

Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile.

Author information

1
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. sebastian.joyce@vanderbilt.edu

Abstract

How innate immune response causes autoimmunity has remained an enigma. In this issue of Cell Host & Microbe, Mattner et al. demonstrate that invariant natural killer T cells activated by the mucosal commensal Novosphingobium aromaticivorans precipitate chronic T cell-mediated autoimmunity against small bile ducts that mirrors human primary biliary cirrhosis. These findings provide a mechanistic understanding of the role of innate immunity toward a microbe in the development of autoimmunity.

PMID:
18474352
DOI:
10.1016/j.chom.2008.04.007
[Indexed for MEDLINE]
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