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Mini Rev Med Chem. 2008 May;8(5):421-8.

Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets.

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1
Department of General, Visceral, Vascular and Thoracic Surgery, - Universitätsmedizin Berlin, Monbijoustrasse 2, 10117 Berlin, Germany.

Abstract

Preclinical studies revealed that curcumin, the yellow curry pigment, emodin, a compound derived from grapes, and taurolidine, derived from a biogenic amino acid, and some of their structural homologs possess anti-angiogenic and cancer chemopreventive properties. Whereas curcumin and emodin can act via inhibition of COP9 signalosome-associated kinases, taurolidine blocks protein biosynthesis.

PMID:
18473931
[Indexed for MEDLINE]
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