Format

Send to

Choose Destination
Int J Eat Disord. 2008 Nov;41(7):602-10. doi: 10.1002/eat.20549.

Implications of starvation-induced change in right dorsal anterior cingulate volume in anorexia nervosa.

Author information

1
Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA. laurie-mccormick@uiowa.edu

Abstract

OBJECTIVE:

Converging evidence suggests a role for the anterior cingulate cortex (ACC) in the pathophysiology of anorexia nervosa (AN). This study sought to determine whether ACC volume was affected by starvation in active AN and, if so, whether this had any clinical significance.

METHOD:

Eighteen patients with active AN and age- and gender-matched normal controls underwent magnetic resonance imaging (MRI). Sixteen patients (89%) with AN had intelligence quotients (IQ) testing at intake, 14 (78%) had repeat MRIs after weight normalization, and 10 (56%) had outcome data at 1-year posthospitalization.

RESULTS:

Right dorsal ACC volume was significantly reduced in active AN patients versus controls and was correlated with lower performance IQ. While ACC normalization occurred with weight restoration, smaller change in right dorsal ACC volume prospectively predicted relapse after treatment.

CONCLUSION:

Reduced right dorsal ACC volume during active AN relates to deficits in perceptual organization and conceptual reasoning. The degree of right dorsal ACC normalization during treatment is related to outcome.

PMID:
18473337
PMCID:
PMC3652574
DOI:
10.1002/eat.20549
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center