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Endocrine. 2008 Apr;33(2):171-5. doi: 10.1007/s12020-008-9068-8. Epub 2008 May 13.

Herpes virus antibodies seroprevalence in children with autoimmune thyroid disease.

Author information

1
Department of Endocrinology, Metabolism and Diabetes, Metaxa Memorial Anticancer Research Hospital, Botasi 51 Str, Piraeus, Greece. thomasproge@endo.gr

Abstract

BACKGROUND:

Elevated titers of antibodies against different herpes virus antigens have been reported in some immunodeficient and systemic autoimmune disorders.

OBJECTIVE:

To examine if Herpes Simplex Virus (HSV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) IgG and IgM antibodies are detected more frequently in children with autoimmune thyroid disease (AITD) compared to controls.

SUBJECTS AND METHODS:

Thirty-four children with AITD, aged 9.62 +/- 2.35 years, and 31 matched controls, aged 9.24 +/- 2.98 years, were studied.

RESULTS:

The percentage of EBV IgG+ children with AITD was statistically higher than the percentage of EBV IgG+ controls (82.35% versus 51.61%, P = 0.008). The percentage of EBV IgG+ children with AITD and hypothyroidism was statistically higher than the percentage of EBV IgG+ children with AITD, without hypothyroidism (100% versus 70%, P = 0.024). No other statistically significant differences were observed in HSV-1+2, and CMV IgG or IgM antibodies between the subgroups of children studied.

CONCLUSIONS:

EBV seroprevalence is higher in children with AITD compared to controls and the underlying pathology remains to be elucidated.

PMID:
18473192
DOI:
10.1007/s12020-008-9068-8
[Indexed for MEDLINE]

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