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Dig Dis Sci. 2008 Dec;53(12):3128-32. doi: 10.1007/s10620-008-0301-3. Epub 2008 May 13.

A glass of water immediately increases gastric pH in healthy subjects.

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Hepatogastroenteroly Unit, 2nd Department of Internal Medicine-Propaedeutic, "Attikon" University General Hospital, Athens University, Athens, Greece.


Onset of action of antisecretory agents is of pivotal importance for patients with gastroesophageal reflux disease (GERD) treated "on-demand."


To study the acute effect of acid-inhibiting drugs and water administration on gastric pH.


A cross-over study was performed in 12 H. pylori (-), healthy subjects (6 men; mean age: 26 years). A single oral dose of the following agents was received with a wash-out period between each study: a glass of water (200 ml), antacid, ranitidine, omeprazole, esomeprazole, and rabeprazole. Gastric pH was recorded for 6 h after drug intake.


Water increased gastric pH >4 in 10/12 subjects after 1 min. The time (median) needed to pH >4 was for: antacid 2 min, ranitidine 50 min, omeprazole 171 min, esomeprazole 151 min, and rabeprazole 175 min. Gastric pH >4 lasted for 3 min after water and for 12 min after antacids; it remained >4 until the end of recording in: 4/12 subjects with ranitidine, 11/12 with rabeprazole, and all with omeprazole and esomeprazole.


Water and antacid immediately increased gastric pH, while PPIs showed a delayed but prolonged effect compared to ranitidine.

[Indexed for MEDLINE]

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