Format

Send to

Choose Destination
See comment in PubMed Commons below
Mamm Genome. 2008 Aug;19(7-8):581-6. doi: 10.1007/s00335-008-9109-x. Epub 2008 May 13.

PiRNA-like RNAs in the marsupial Monodelphis domestica identify transcription clusters and likely marsupial transposon targets.

Author information

1
Molecular Genetics and Biophysics, Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241, USA. rdevor@idtdna.com

Abstract

PIWI-interacting RNAs (piRNAs) are a recently discovered class of small noncoding RNAs that have been detected in human, mouse, rat, zebrafish, and Drosophila genomes. We have utilized a size-directed small-RNA cloning procedure to clone and map more than 300 candidate piRNA-like small RNAs in the genome of the marsupial species Monodelphis domestica. Our results are consistent with those from other species in that the piRNA-like candidate sequences range in size from 28 to 31 nucleotides, show a pronounced preference for uridine at the 5' end, are transcribed from a few large clusters, appear to target transposons, and display virtually no sequence conservation.

PMID:
18473137
DOI:
10.1007/s00335-008-9109-x
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center