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Trends Genet. 2008 Jun;24(6):259-62. doi: 10.1016/j.tig.2007.09.006. Epub 2008 May 9.

The urbilaterian Super-Hox cluster.

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  • 1Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.

Abstract

Comparison of whole genome sequences of representative animals enables reconstruction of the ancestral bilaterian genome: the starting point from which most extant animal lineages evolved. The Hox gene cluster patterns the anterior-posterior axis of bilaterians. Here we show that this cluster was embedded within a larger homeobox gene cluster, the Super-Hox cluster, in the ancestral bilaterian. This Super-Hox cluster contained at least eight genes alongside the core Hox genes ('EuHox' genes).

PMID:
18472178
DOI:
10.1016/j.tig.2007.09.006
[PubMed - indexed for MEDLINE]
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