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Nat Cell Biol. 2008 Jun;10(6):748-51. doi: 10.1038/ncb1738. Epub 2008 May 11.

Extra centrosomes and/or chromosomes prolong mitosis in human cells.

Author information

1
Division of Molecular Medicine, Wadsworth Center, N.Y.S. Department of Health, Empire State Plaza, Albany, New York 12201-0509, USA.

Abstract

Using laser microsurgery and cell fusion we have explored how additional centrosomes and/or chromosomes influence the duration of mitosis in human cells. We found that doubling the chromosome number added approximately 10 min to a 20 min division, whereas doubling the number of centrosomes added approximately 30 min more. Extra centrosomes and/or chromosomes prolong mitosis by delaying satisfaction of the spindle assembly checkpoint. Thus mitosis can be prolonged by non-genetic means and extra chromosomes and centrosomes probably contribute to the elevated mitotic index seen in many tumours.

PMID:
18469805
PMCID:
PMC2430725
DOI:
10.1038/ncb1738
[Indexed for MEDLINE]
Free PMC Article

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