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J Occup Environ Med. 2008 May;50(5):550-60. doi: 10.1097/JOM.0b013e318162f640.

Mortality among workers exposed to acrylonitrile in fiber production: an update.

Author information

1
Epidemiology Program, DuPont Haskell Global Centers for Health and Environmental Sciences, EI du Pont de Nemours and Company, Newark, Delaware 19714, USA. J-Morel.Symons@usa.dupont.com

Abstract

OBJECTIVE:

The investigation updates the mortality experience through 2002 for a cohort of workers exposed to acrylonitrile (AN).

METHODS:

Standardized mortality ratios (SMR) were estimated based on two reference populations: the US population and a regional employee population. Exposure-response analyses were conducted using Cox regression models for cumulative and mean intensity exposure measures.

RESULTS:

In the cohort of 2548 workers, 839 deaths have occurred with 91 deaths due to respiratory system cancer. Most standardized mortality ratio estimates are at or near no-effects levels. Hazard ratio (HR) estimates indicate no increased mortality risk for respiratory system cancer (adjusted HR = 0.96, 95% confidence interval: 0.74, 1.25).

CONCLUSIONS:

In summary, no mortality outcome of a priori interest, principally respiratory system cancer, is associated with increased AN exposure among fiber production workers over five decades of follow-up.

PMID:
18469624
DOI:
10.1097/JOM.0b013e318162f640
[Indexed for MEDLINE]

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