Format

Send to

Choose Destination
See comment in PubMed Commons below
DNA Repair (Amst). 2008 Jul 1;7(7):1077-86. doi: 10.1016/j.dnarep.2008.03.009. Epub 2008 May 12.

Poly ADP-ribose polymerase-1: an international molecule of mystery.

Author information

1
Medical Research Council Radiation Oncology & Biology Unit, University of Oxford, Oxford OX3 7DQ, UK.

Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the most abundant proteins within mammalian cells. First described more than 45 years ago, PARP-1 has been the subject of many studies and was shown to be involved in multiple aspects of cellular metabolism. Despite many interesting studies that implicate PARP-1 in transcription, chromatin remodelling, apoptosis, DNA repair and several neurological disorders, its precise role is still unclear. This review will discuss the role of PARP-1 in DNA repair and propose a model whereby PARP-1 operates as a modulator of base excision repair capacity.

PMID:
18468963
DOI:
10.1016/j.dnarep.2008.03.009
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center