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Bioorg Med Chem Lett. 2008 Jun 1;18(11):3236-41. doi: 10.1016/j.bmcl.2008.04.050. Epub 2008 Apr 25.

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.

Author information

1
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. jared.cumming@spcorp.com

Erratum in

  • Bioorg Med Chem Lett. 2008 Aug 1;18(15):4447.

Abstract

Guided by structure-based design, we synthesized two novel series of potent inhibitors of BACE1 and generated extensive SAR around both the prime and non-prime side binding pockets. The key feature of both series is a cyclic amine motif specifically crafted to achieve interactions with both the flap and with the S2' pocket.

PMID:
18468890
DOI:
10.1016/j.bmcl.2008.04.050
[Indexed for MEDLINE]

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