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Curr Opin Cell Biol. 2008 Jun;20(3):303-9. doi: 10.1016/j.ceb.2008.03.012. Epub 2008 May 28.

Transcriptional targets of sirtuins in the coordination of mammalian physiology.

Author information

1
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, France.

Abstract

Sirtuins (Sirts) compose a family of NAD(+)-dependent deacetylases and/or ADP-ribosyltransferases, which have been implicated in aging, metabolism, and tolerance to oxidative stress. Many of the biological processes regulated by Sirts result from the adaptation of complex gene-expression programs to the energetic state of the cell, sensed through NAD(+) levels. To that respect, Sirts, and particularly the founding member of the family Sirt1, have emerged as important regulators of transcription, which they modulate both positively and negatively by targeting histones and transcriptional complex regulatory proteins. This review will focus on recent advances that have started deciphering how mammalian Sirts regulate transcriptional networks and thereby control physiology.

PMID:
18468877
PMCID:
PMC2447870
DOI:
10.1016/j.ceb.2008.03.012
[Indexed for MEDLINE]
Free PMC Article

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