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Int J Biochem Cell Biol. 2008;40(10):1971-8. doi: 10.1016/j.biocel.2008.03.018. Epub 2008 Apr 1.

LINGO-1 and its role in CNS repair.

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Biogen Idec Inc., 14 Cambridge Center, Cambridge, MA 02142, United States.


LINGO-1 is selectively expressed in the CNS on both oligodendrocyte precursor cells (OPCs) and neurons. Its expression is developmentally regulated in the normal CNS, as well as up-regulated in human or rat models of neuropathologies. LINGO-1 functions as a negative regulator of oligodendrocyte differentiation and myelination, neuronal survival and axonal regeneration. Across diverse animal CNS disease models, targeted LINGO-1 inhibition was found to promote neuron and oligodendrocyte survival, axon regeneration, oligodendrocyte differentiation, remyelination and improved functional recovery. The targeted inhibition of LINGO-1 therefore presents a novel therapeutic approach for the treatment of neurological diseases.

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