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J Ethnopharmacol. 2008 Jun 19;118(1):113-7. doi: 10.1016/j.jep.2008.03.016. Epub 2008 Mar 29.

Anti-inflammatory activity of phylligenin, a lignan from the fruits of Forsythia koreana, and its cellular mechanism of action.

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1
College of Pharmacy, Kangwon National University, Chunchon, Republic of Korea.

Abstract

AIM OF THE STUDY:

The fruits of Forsythia koreana have long been used in Chinese medicine to treat inflammatory disorders. However, the pharmacological data is not sufficient to clearly establish a scientific rationale for the anti-inflammatory medicinal use of this plant material, and the search for its active principles has been limited so far.

MATERIALS AND METHODS:

Phylligenin (lignan) was isolated from the fruits of Forsythia koreana and its anti-inflammatory activity was examined.

RESULTS AND CONCLUSION:

Phylligenin (1-100 microM) and the methanol extract of Forsythia koreana fruits inhibited cyclooxygenase-2 (COX-2)-mediated prostaglandin E(2) and inducible nitric oxide synthase (iNOS)-mediated nitric oxide (NO) synthesis from lipopolysaccharide-treated RAW 264.7 cells. In the mechanism study, phylligenin inhibited iNOS expression and nuclear factor-kappaB (NF-kappaB) activation but had no effect on COX-2 expression. Moreover, phylligenin significantly inhibited mouse carrageenan-induced paw edema by intraperitoneal administration (22.1-34.7% inhibition at 12.5-100 mg/kg). These pharmacological properties indicate that phylligenin possesses significant anti-inflammatory activity in vitro and in vivo, and may provide the scientific rationale for anti-inflammatory use of the fruits of Forsythia koreana.

PMID:
18467047
DOI:
10.1016/j.jep.2008.03.016
[Indexed for MEDLINE]

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