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BMC Proc. 2007;1 Suppl 1:S124. Epub 2007 Dec 18.

Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors.

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1
Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA. hjhsieh@gene.com

Abstract

Non-inherited maternal antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss possible reasons why our result conflicts with several previous studies (including one of our own) that used RA patients from northern Europe.

PMID:
18466466
PMCID:
PMC2367472
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