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Cardiovasc Ther. 2008 Spring;26(1):38-49. doi: 10.1111/j.1527-3466.2007.00036.x.

Use of antihypertensive drugs during pregnancy and lactation.

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  • 1Section of Cardiology, Department of Medicine, The Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA.


The decision to treat elevated arterial pressure in pregnancy depends on the risk and benefits imposed on the mother and the fetus. Treatment for mild-to-moderate hypertension during pregnancy may not reduce maternal or fetal risk. Severe hypertension, on the other hand, should be treated to decrease maternal risk. Methyldopa and beta-adrenoceptor antagonists have been used most extensively. In acute severe hypertension, intravenous labetalol or oral nifedipine are reasonable choices.

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