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J Neuroimaging. 2008 Jul;18(3):227-36. doi: 10.1111/j.1552-6569.2007.00180.x. Epub 2008 Mar 7.

Functional imaging of stroke recovery: an ecological review from a neural network perspective with an emphasis on motor systems.

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  • 1Stroke Clinic, Brain Health Clinic, Baycrest Centre for Geriatric Care, Toronto, Canada. jween@klaru-baycrest.on.ca

Abstract

Functional imaging is beginning to outline the brain's functional architecture and mechanisms of recovery from injury. I will review primarily the motor-function literature from normal populations, learning trials, stroke recovery, and rehabilitation with a neural network approach that may prove fruitful in further advancing our understanding of brain plasticity in response to focal lesions. A key consideration in this review will be how the development of distributed motor networks might constrain recovery as a function of the altered connectivity between damaged and nondamaged areas. It will be argued that this connectivity is central to both recovery from injury and response to treatment.

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