Format

Send to

Choose Destination
Arch Pathol Lab Med. 2008 May;132(5):838-46. doi: 10.1043/1543-2165(2008)132[838:SOTAIT]2.0.CO;2.

State of the art in trueness and interlaboratory harmonization for 10 analytes in general clinical chemistry.

Author information

1
Department of Pathology, Virginia Commonwealth University, PO Box 980286, Richmond, VA 23298-0286, USA. gmiller@vcu.edu

Abstract

CONTEXT:

Harmonization and standardization of results among different clinical laboratories is necessary for clinical practice guidelines to be established.

OBJECTIVE:

To evaluate the state of the art in measuring 10 routine chemistry analytes.

DESIGN:

A specimen prepared as off-the-clot pooled sera and 4 conventionally prepared specimens were sent to participants in the College of American Pathologists Chemistry Survey. Analyte concentrations were assigned by reference measurement procedures.

PARTICIPANTS:

Approximately 6000 clinical laboratories.

RESULTS:

For glucose, iron, potassium, and uric acid, more than 87.5% of peer groups meet the desirable bias goals based on biologic variability criteria. The remaining 6 analytes had less than 52% of peer groups that met the desirable bias criteria.

CONCLUSIONS:

Routine measurement procedures for some analytes had acceptable traceability to reference systems. Conventionally prepared proficiency testing specimens were not adequately commutable with a fresh frozen specimen to be used to evaluate trueness of methods compared with a reference measurement procedure.

Comment in

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Allen Press, Inc.
Loading ...
Support Center