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J Proteome Res. 2008 Jun;7(6):2262-9. doi: 10.1021/pr700686x. Epub 2008 May 9.

A connection between the mitochondrial permeability transition pore, autophagy, and cerebral amyloidogenesis.

Author information

1
ProteoSys AG, Carl Zeiss Strasse 51, D-55129 Mainz, Germany.

Abstract

In a drug reprofiling attempt, we explored novel neuroprotective properties of 4-azasteroids by synthesizing chemical affinity tags capturing adenine nucleotide translocator-1, as a potential target. Dutasteride inhibits the mitochondrial transition pore and induces an increase of autophagosomal structures in human cell lines. In vivo, a surprising reduction of the beta-amyloid plaque load in a model for cerebral amyloidosis appears to connect release of neurotoxic peptides, mitochondrial apoptosis and autophagy.

PMID:
18465891
DOI:
10.1021/pr700686x
[Indexed for MEDLINE]

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