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Am J Addict. 2008 May-Jun;17(3):187-94. doi: 10.1080/10550490802020160.

Suicidality in opioid-dependent subjects.

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Clinical Research and Evaluation Facility, Nathan S. Kline Institute for Psychiatric Research and Rockland Psychiatric Center, Orangeburg, New York, USA.


We determined suicide attempt characteristics in 160 opioid-dependent subjects. Three aspects of suicide vulnerability were also examined: familial aggregation of suicidal behaviors, degree of aggression/impulsivity, and smoking. Forty-eight percent of subjects had a personal history of suicide attempt. A personal history of suicide attempt was associated with an early onset of heroin use, but not with gender differences. A family history of suicide was a progressive risk factor for suicide attempt. Subjects with a personal history of suicide attempt had a higher degree of aggression/impulsivity and smoked more cigarettes. In conclusion, opioid-dependent subjects who attempt suicide show familial aggregation and clinical expressions of suicidal liability similar to those described in other psychiatric groups.

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