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Eur Arch Otorhinolaryngol. 2008 Dec;265(12):1465-9. doi: 10.1007/s00405-008-0689-6. Epub 2008 May 8.

Potential efficacy of early treatment of acute acoustic trauma with steroids and piracetam after gunshot noise.

Author information

1
1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA Hospital 1, Stilponos Kyriakidi St., 540 06, Thessaloniki, Greece. psillasgeo@the.forthnet.gr

Abstract

The purpose of this randomized study was to evaluate the early effect of the treatment of acute acoustic trauma (AAT) with steroids and piracetam in a sample of 52 young soldiers who were exposed to intense gunfire noise (G3 rifle). These patients were divided into three groups: (1) group A (20 patients) in which the treatment began within the first hour after the AAT, (2) group B (17 patients) in which the treatment started more than 1 h later and less than 16 h after the AAT and (3) group C (15 patients) in which the treatment began after 24 h or more. One month after the treatment onset, 36 (69%) patients of all the groups showed hearing improvement (complete-partial recovery) in the pure tone audiometry. The greater number of patients who showed complete recovery after AAT was noted in group A (65%) compared to group B (23.5%) and C (13.3%). Moreover, in group A, in the final audiogram, the averaged hearing threshold was statistically better (P < 0.001) than that of groups B and C. In spite of the lack of control group, our data demonstrated the possible effectiveness of the immediate onset of treatment of AAT.

PMID:
18463885
DOI:
10.1007/s00405-008-0689-6
[Indexed for MEDLINE]

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