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Echocardiography. 2008 Aug;25(7):764-7. doi: 10.1111/j.1540-8175.2008.00691.x. Epub 2008 May 7.

Acute systolic dysfunction within two weeks of high-dose chemotherapy conditioning before autologous bone marrow transplant: a case report.

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Department of Internal Medicine, Health Sciences Center, University of Oklahoma, Oklahoma City, Oklahoma 73104, USA.


Studies have shown various cardiotoxic effects of high-dose chemotherapy (HDC) used for conditioning before autologous bone marrow transplant (ABMT) including arrhythmias but only a transient small decrease in left ventricle ejection fraction (LVEF). To our knowledge, an acute dramatic decrease in LVEF after HDC preconditioning has never been reported. We report a patient presenting with an acutely symptomatic heart failure within 2 weeks of receiving HDC conditioning for ABMT with an LVEF drop from normal to <30%. With stringent management and follow-up with regular echocardiograms for medication reconciliation, 5 months later she regained her LVEF of 50%.

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