Format

Send to

Choose Destination
Nature. 1991 Jan 24;349(6307):305-10.

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence.

Author information

1
Department of Physiology, University of California, San Francisco.

Abstract

Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.

PMID:
1846229
DOI:
10.1038/349305a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center