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J Cell Physiol. 2008 Aug;216(2):337-46. doi: 10.1002/jcp.21491.

Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals.

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  • 1Developmental Skin Biology Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA.

Abstract

Homeobox genes are an evolutionarily conserved class of transcription factors that are key regulators during developmental processes such as regional specification, patterning, and differentiation. In this review, we summarize the expression pattern, loss- and/or gain-of-function mouse models, and naturally occurring mouse and human mutations of known homeobox genes required for the development of ectodermal appendages.

PMID:
18459147
PMCID:
PMC2561923
DOI:
10.1002/jcp.21491
[PubMed - indexed for MEDLINE]
Free PMC Article
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