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Diabetes Care. 2008 Aug;31(8):1582-4. doi: 10.2337/dc08-0025. Epub 2008 May 5.

Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study.

Author information

1
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. foxca@nhlbi.nih.gov

Abstract

OBJECTIVE:

We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes.

RESEARCH DESIGN AND METHODS:

Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years.

RESULTS:

Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men.

CONCLUSIONS:

The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.

PMID:
18458146
PMCID:
PMC2494632
DOI:
10.2337/dc08-0025
[Indexed for MEDLINE]
Free PMC Article

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