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Genetics. 2008 May;179(1):249-62. doi: 10.1534/genetics.107.076877. Epub 2008 May 5.

Genome integrity is regulated by the Caenorhabditis elegans Rad51D homolog rfs-1.

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1
Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21218, USA.

Abstract

Multiple mechanisms ensure genome maintenance through DNA damage repair, suppression of transposition, and telomere length regulation. The mortal germline (Mrt) mutants in Caenorhabditis elegans are defective in maintaining genome integrity, resulting in a progressive loss of fertility over many generations. Here I show that the high incidence of males (him)-15 locus, defined by the deficiency eDf25, is allelic to rfs-1, the sole rad-51 paralog group member in C. elegans. The rfs-1/eDf25 mutant displays a Mrt phenotype and mutant animals manifest features of chromosome fusions prior to the onset of sterility. Unlike other Mrt genes, rfs-1 manifests fluctuations in telomere lengths and functions independently of telomerase. These data suggest that rfs-1 is a novel regulator of genome stability.

PMID:
18458109
PMCID:
PMC2390604
DOI:
10.1534/genetics.107.076877
[Indexed for MEDLINE]
Free PMC Article
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