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J Am Chem Soc. 2008 May 28;130(21):6722-4. doi: 10.1021/ja8016973. Epub 2008 May 6.

Structural basis of DNA quadruplex recognition by an acridine drug.

Author information

1
Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

Abstract

The crystal structure of a complex between the bimolecular human telomeric quadruplex d(TAGGGTTAGGGT)2 and the experimental anticancer drug BRACO-19, has been determined, to 2.5 A resolution. The binding site for the BRACO-19 molecule is at the interface of two parallel-folded quadruplexes, sandwiched between a G-tetrad surface and a TATA tetrad, and held in the site by networks of water molecules. The structure rationalizes the existing structure-activity data and provides a starting-point for the structure-based design of quadruplex-binding ligands.

PMID:
18457389
DOI:
10.1021/ja8016973
[Indexed for MEDLINE]

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