Format

Send to

Choose Destination
J Bacteriol. 2008 Jul;190(13):4782-5. doi: 10.1128/JB.00025-08. Epub 2008 May 2.

Identification of the L,D-transpeptidases for peptidoglycan cross-linking in Escherichia coli.

Author information

1
INSERM U872-LRMA, Equipe 12, Centre de Recherche des Cordeliers, 15 Rue de l'Ecole de Médecine, 75270 Paris, Cedex 06, France.

Abstract

Three active-site cysteine L,D-transpeptidases can individually anchor the Braun lipoprotein to the Escherichia coli peptidoglycan. We show here that two additional enzymes of the same family form peptide bonds between the third residues of peptidoglycan stems, generating meso-DAP(3)-->meso-DAP(3) unusual cross-links. This activity partially replaces the D,D-transpeptidase activity of penicillin-binding proteins.

PMID:
18456808
PMCID:
PMC2446776
DOI:
10.1128/JB.00025-08
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center