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Curr Opin Immunol. 2008 Apr;20(2):158-61. doi: 10.1016/j.coi.2008.03.015. Epub 2008 May 2.

BAFF and the plasticity of peripheral B cell tolerance.

Author information

1
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, United States.

Abstract

BAFF and its receptors play a crucial role in peripheral B cell selection and survival, by dictating the set point for mature primary B cell numbers and adjusting thresholds for specificity-based selection during transitional differentiation. The notion that selective stringency can be varied on the basis of homeostatic demands reveals a previously unappreciated degree of plasticity in B cell tolerance, and suggests a paradigm that unites peripheral negative and positive selection with the maintenance of mature B cell numbers. Moreover, it implies a developmentally regulated coupling of BCR and BAFF receptors at the transitional stages and beyond.

PMID:
18456486
PMCID:
PMC2556951
DOI:
10.1016/j.coi.2008.03.015
[Indexed for MEDLINE]
Free PMC Article

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