Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Cogn. 2008 Nov;68(2):134-43. doi: 10.1016/j.bandc.2008.03.008. Epub 2008 May 5.

Neural substrates of cognitive skill learning in Parkinson's disease.

Author information

1
Département de Psychologie, Université de Montréal, C.P. 6128 Succursale Centre-Ville, Montreal, Que., Canada.

Abstract

While cognitive skill learning is normally acquired implicitly through frontostriatal circuitry in healthy individuals, neuroimaging studies suggest that patients with Parkinson's disease (PD) do so by activating alternate, intact brain areas associated with explicit memory processing. To further test this hypothesis, 10 patients with PD and 12 healthy controls were tested on a modified, learning version of the Tower of London task while undergoing positron emission tomography at four different time points over the course of learning. Despite having less accurate problem solving abilities than controls, PD patients were able to acquire the skill learning task. However, as compared to controls, they maintained higher levels of cerebral blood flow activity in the dorsolateral prefrontal cortex and hippocampus and showed an increase in activity in the frontopolar cortex and posterior cingulate over the course of learning. These findings reflect a shift to the explicit memory system in PD patients, enabling them to learn this cognitive skill, which is normally acquired by control subjects using implicit learning strategies and frontostriatal circuitry.

PMID:
18456379
DOI:
10.1016/j.bandc.2008.03.008
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center