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Am J Obstet Gynecol. 2008 Aug;199(2):127.e1-6. doi: 10.1016/j.ajog.2008.03.012. Epub 2008 May 5.

A national study of the complications of lupus in pregnancy.

Author information

1
Department of Medicine, Division of Rheumatology and Immunology, Duke University School of Medicine, Durham, NC 27710, USA. megan.clowse@duke.edu

Abstract

OBJECTIVE:

This study was undertaken to determine the risk of rare complications during pregnancy for women with systemic lupus erythematosus.

STUDY DESIGN:

By using the Nationwide Inpatient Sample from 2000-2003, we compared maternal and pregnancy complications for all pregnancy-related admissions for women with and without systemic lupus erythematosus.

RESULTS:

Of more than 16.7 million admissions for childbirth over the 4 years, 13,555 were to women with systemic lupus erythematosus. Maternal mortality was 20-fold higher among women with systemic lupus erythematosus. The risks for thrombosis, infection, thrombocytopenia, and transfusion were each 3- to 7-fold higher for women with systemic lupus erythematosus. Lupus patients also had a higher risk for cesarean sections (odds ratio: 1.7), preterm labor (odds ratio: 2.4), and preeclampsia (odds ratio: 3.0) than other women. Women with systemic lupus erythematosus were more likely to have other medical conditions, including diabetes, hypertension, and thrombophilia, that are associated with adverse pregnancy outcomes.

CONCLUSION:

Women with systemic lupus erythematosus are at increased risk for serious medical and pregnancy complications during pregnancy.

PMID:
18456233
PMCID:
PMC2542836
DOI:
10.1016/j.ajog.2008.03.012
[Indexed for MEDLINE]
Free PMC Article

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