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Biochim Biophys Acta. 2008 Sep;1781(9):582-7. doi: 10.1016/j.bbalip.2008.04.001. Epub 2008 Apr 11.

Lysophosphatidic acid and renal fibrosis.

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1
Inserm, U858/I2MR, Department of Metabolism and Obesity, Team #3, 1 Avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.

Abstract

The development of fibrosis involves a multitude of events and molecules. Until now the majority of these molecules were found to be proteins or peptides. But recent data show significant involvement of the phospholipid lysophosphatidic acid (LPA) in the development of pulmonary, liver and renal fibrosis. The latest data on the role of LPA and the G-protein-coupled LPA1 receptor in the development of renal fibrosis will be discussed. LPA1-receptor activation was found to be associated with increased vascular leakage and increased fibroblast recruitment in pulmonary fibrosis. Furthermore, in renal fibrosis LPA1-receptor activation stimulates macrophage recruitment and connective tissue growth factor expression. The observations make this receptor an interesting alternative and new therapeutic target in fibrotic diseases.

PMID:
18455518
PMCID:
PMC2577601
DOI:
10.1016/j.bbalip.2008.04.001
[Indexed for MEDLINE]
Free PMC Article
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