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Cancer Cell. 2008 May;13(5):385-93. doi: 10.1016/j.ccr.2008.03.015.

Survival of cancer cells is maintained by EGFR independent of its kinase activity.

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1
Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Abstract

Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).

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PMID:
18455122
PMCID:
PMC2413063
DOI:
10.1016/j.ccr.2008.03.015
[Indexed for MEDLINE]
Free PMC Article

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