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Cancer Cell. 2008 May;13(5):379-80. doi: 10.1016/j.ccr.2008.04.010.

PIKK-ing a new partner: a new role for PKB in the DNA damage response.

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Department of Biochemistry & Molecular Biology, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.


The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-damaging agents, such as ionizing radiation. In a recent paper published in Molecular Cell, Hemmings and colleagues provide evidence that DNA-PK is required for the activation of PKB in response to exposure to ionizing radiation, suggesting that these two protein kinases may act together to promote survival after DNA damage.

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