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Pediatr Blood Cancer. 2008 Sep;51(3):428-30. doi: 10.1002/pbc.21586.

Measurement of cerebrospinal fluid protein is unnecessary in children with leukemia.

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Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, NC 27157, USA.


To determine the incidence and importance of abnormal cerebrospinal fluid (CSF) protein in children with acute leukemia, we performed a retrospective chart review. On 160 pediatric patients a total of 2,172 LPs were performed (median per patient = 15; range 1-38). Overall, 314 (14%) of CSF protein measurements were abnormal: 141 (7%) were abnormally low (<15 mg/dL) and 158 (7%) were abnormally high (>45 mg/dL). In no case did an abnormal CSF protein impact patient management. We conclude that routine measurement of CSF protein is not indicated in children with acute leukemia.

[Indexed for MEDLINE]

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