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Klin Monbl Augenheilkd. 2008 May;225(5):443-5. doi: 10.1055/s-2008-1027362.

[Orbital fat atrophy in glaucoma patients treated with topical bimatoprost--can bimatoprost cause enophthalmos?].

[Article in German]

Author information

1
Klinik und Poliklinik für Augenheilkunde, Inselspital, Universität Bern, Schweiz. christoph.tappeiner@insel.ch

Abstract

PURPOSE:

The aim of this communication is to report enophthalmos as a possible new adverse effect of topical bimatoprost treatment.

PATIENTS AND METHODS:

A retrospective case series of five glaucoma patients under long-term topical bimatoprost treatment was evaluated. Documentation with photo and Hertel exophthalmometry was reviewed.

RESULTS:

In all five patients a deep lid sulcus, reduced infraocular fat pads and enophthalmos-suspicious Hertel values were found (mean 11.9 mm; SD 2.4). Other aetiologies for enophthalmos were excluded anamnestically and by clinical examination.

CONCLUSION:

Bimatoprost may lead to an alteration of the eyelid with deepening of the lid sulcus and may also be responsible for an iatrogenic orbital fat atrophy. A possible mechanism of action might be the induction of apoptosis of orbital fibroblasts with a remodelling of the extracellular matrix. Prospective studies are necessary to confirm this cross-sectional observation.

PMID:
18454393
DOI:
10.1055/s-2008-1027362
[Indexed for MEDLINE]

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