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ScientificWorldJournal. 2008 Apr 14;8:364-70. doi: 10.1100/tsw.2008.55.

Diffusion-weighted MR imaging in diagnosis of superficial and invasive urinary bladder carcinoma: a preliminary prospective study.


We conducted a prospective study to demonstrate the feasibility of using diffusion-weighted (DW) magnetic resonance imaging (MRI) for the detection of urinary bladder carcinomas. Between January to June 2007, 43 patients with single bladder tumor were included in our study. Before taking a biopsy, DW MRI was obtained in the axial plane under free breathing scanning with a multisection, spin-echo type, single-shot echo planar sequence with a body coil. Moreover, the apparent diffusion coefficient (ADC) value was measured in a circular region of interest within the carcinoma, urine, normal bladder wall, prostate, and seminal vesicle. All carcinomas in the 43 patients were clearly shown as high signal intensity relative to the surrounding structure. The sensitivity and positive predictive values of DW MRI were 100% in terms of correctly detecting the carcinomas. The ADC value in the carcinoma (1.40 +/- 0.51) was significantly lower compared with that of urine (3.50 +/- 0.43) (p < 0.001), normal bladder wall (2.29 +/- 0.78) (p < 0.001), peripheral zone of prostate (1.77 +/- 0.44) (p < 0.05), transition zone of prostate (1.88 +/- 0.54) (p < 0.05), and the seminal vesicle (2.12 +/- 0.43) (p < 0.001). There was no statistical difference in ADC values between different histological subtypes. There was no overlap between the ADC values of the tumors and the urine, but there was no clear cutoff between the tumor and bladder wall, prostate, or seminal vesicles. Bladder carcinomas have significantly lower ADC when compared to surroundings. Clinical experience with this method is still preliminary and further studies are required.

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