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AIDS. 2008 May 11;22(8):990-2. doi: 10.1097/QAD.0b013e3282ff884e.

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.

Author information

1
Division of Experimental Medicine, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California 94110, USA. lishomwa.ndhlovu@ucsf.edu

Abstract

IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

PMID:
18453860
PMCID:
PMC2850608
DOI:
10.1097/QAD.0b013e3282ff884e
[Indexed for MEDLINE]
Free PMC Article

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