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Am J Clin Nutr. 1991 Apr;53(4 Suppl):1068S-1070S. doi: 10.1093/ajcn/53.4.1068S.

A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors.

Author information

1
Department of Human Oncology, University of Wisconsin-Madison 53792.

Abstract

Two forms of vitamin E, tocopherol and tocotrienol, were tested for chemopreventive activity in two chemically induced rat mammary-tumor models. When mammary tumors were induced by 7,12-dimethylbenz(a)anthracene (DMBA, 50 mg/kg), only the tocotrienol group had a statistically significant increase in tumor latency. There was no effect of either compound on tumor multiplicity. When tumors were induced by N-nitrosomethylurea (NMU, 30 mg/kg), neither analogue of vitamin E modified latency, whereas tocotrienol increased tumor multiplicity. In summary, neither vitamin analog had a major impact on mammary-tumor development after tumor induction with either DMBA or NMU.

PMID:
1845366
DOI:
10.1093/ajcn/53.4.1068S
[Indexed for MEDLINE]

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