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Biofilm development with an emphasis on Bacillus subtilis.

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Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.


Our understanding of the molecular mechanisms involved in biofilm formation has increased tremendously in recent years. From research on diverse bacteria, a general model of bacterial biofilm development has emerged. This model can be adjusted to fit either of two common modes of unicellular existence: nonmotile and motile. Here we provide a detailed review of what is currently known about biofilm formation by the motile bacterium Bacillus subtilis. While the ability of bacteria to form a biofilm appears to be almost universal and overarching themes apply, the combination of molecular events necessary varies widely, and this is reflected in the other chapters of this book.

[Indexed for MEDLINE]
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