Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2008 Jun 18;582(14):2075-85. doi: 10.1016/j.febslet.2008.04.035. Epub 2008 Apr 29.

Directional sensing during chemotaxis.

Author information

1
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.

Abstract

Cells have the innate ability to sense and move towards a variety of chemoattractants. We investigate the pathways by which cells sense and respond to chemoattractant gradients. We focus on the model system Dictyostelium and compare our understanding of chemotaxis in this system with recent advances made using neutrophils and other mammalian cell types, which share many molecular components and signaling pathways with Dictyostelium. This review also examines models that have been proposed to explain how cells are able to respond to small differences in ligand concentrations between the anterior leading edge and posterior of the cell. In addition, we highlight the overlapping functions of many signaling components in diverse processes beyond chemotaxis, including random cell motility and cell division.

PMID:
18452713
PMCID:
PMC2519798
DOI:
10.1016/j.febslet.2008.04.035
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center