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Cleft Palate Craniofac J. 2008 May;45(3):267-71. doi: 10.1597/06-174.

Family-based association study of the MTHFR polymorphism C677T in patients with nonsyndromic cleft lip and palate from central Europe.

Author information

1
Institute of Human Genetics, University of Bonn, Bonn, Germany. reutter@uni-bonn.de

Abstract

OBJECTIVE:

The 677C-->T allele in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been implicated in the etiology of nonsyndromic cleft lip and palate (CL/P). This study involved a family-based association study of the MTHFR polymorphism.

PATIENTS/PARTICIPANTS:

We examined 181 patients with CL/P of central European descent and their parents for this variant.

RESULTS:

The transmission disequilibrium test (TDT) did not confirm an association between the MTHFR 677C-->T polymorphism and nonsyndromic CL/P as previously suggested (p = .36). When comparing the offspring of mothers with periconceptional use of folate to those without, no statistically significant differences were found (p = .708).

CONCLUSION:

Our data suggest that the MTHFR 677C-->T polymorphism does not make a major contribution to the occurrence of CL/P among central Europeans.

PMID:
18452350
DOI:
10.1597/06-174
[Indexed for MEDLINE]

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