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Org Lett. 2008 Jun 5;10(11):2287-90. doi: 10.1021/ol800701j. Epub 2008 May 2.

Hexadecameric self-assembled dendrimers built from 2'-deoxyguanosine derivatives.

Author information

1
Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico.

Abstract

Herein we describe the construction of hexadecameric self-assembled dendrimers (SADs) using a series of dendronized 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) subunits. The azido-substituted mAG subunits were covalently linked to alkynyl polyester dendrons using a copper-catalyzed 1,3-dipolar cycloaddition reaction. Discrete SADs are formed with high fidelity and thermal stability even with the increased steric hindrance offered by the dendrons.

PMID:
18452304
PMCID:
PMC2654094
DOI:
10.1021/ol800701j
[Indexed for MEDLINE]
Free PMC Article

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