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J Nat Med. 2008 Oct;62(4):436-40. doi: 10.1007/s11418-008-0254-z. Epub 2008 May 2.

Anti-inflammatory effect of Pinus sibirica oil extract in animal models.

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Interregional Center Adaptogen, 47/5, Piskarevsky pr., St-Petersburg, 195067, Russia.


The anti-inflammatory effect of the oil extract of seeds of Pinus sibirica Du Tour was evaluated and compared with phenylbutazone. Oral administration of this extract at a dose of 300 mg/kg showed anti-inflammatory activity in the carrageenin-induced edema test in rats. In addition, P. sibirica oil extract showed analgesic properties in the hot-plate test and antipyretic properties in adjuvant-induced local hyperthermia, both in rats. In conclusion, these results provide evidence for the potential usefulness of P. sibirica oil extract, a defined mixture of long-chain polyunsaturated fatty acids, sterols, tocopherols and polyphenols, in inflammatory disorders.

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