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J Mol Neurosci. 2008 Jul;35(3):331-7. doi: 10.1007/s12031-008-9068-4. Epub 2008 May 2.

MicroRNA expression profile in murine central nervous system development.

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Department of Medical Genetics, Faculty of Medical Sciences, University of Campinas-UNICAMP, Tessália Vieira de Camargo 126, Campinas, Sao Paulo, Brazil.


MicroRNAs (miRNAs) regulate gene expression in a post-transcriptional sequence-specific manner. In order to better understand the possible roles of miRNAs in central nervous system (CNS) development, we examined the expression profile of 104 miRNAs during murine brain development. We obtained brain samples from animals at embryonic days (E) E15, E17, and postnatal days (P) P1 and P7. Total RNA was isolated from tissue and used to obtain mature miRNAs by reverse transcription. Our results indicate that there is a group of 12 miRNAs that show a distinct expression profile, with the highest expression during embryonic stages and decreasing significantly during development. This profile suggests key roles in processes occurring during early CNS development.

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